RITUXIMAB IN THE TREATMENT OF FOLLICULAR LYMPHOMA: THE FUTURE OF BIOSIMILARS IN THE EVOLVING THERAPEUTIC LANDSCAPE


Chromatin dynamics at the maternal to zygotic transition: recent advances from the zebrafish model [version 1; peer review: 2 approved]

Early animal development is characterized by intense reorganization of the embryonic genome, including large-scale changes moen finney in chromatin structure and in the DNA and histone modifications that help shape this structure.Particularly profound shifts in the chromatin landscape are associated with the maternal-to-zygotic transition, when the

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Visual Metaphors in Pedagogical Discourse

A visual metaphor is an image that allows you convey the meaning that escapes during verbal representation, as well as to enhance the impact of the message.It is for this reason that visual metaphor occupies a special place in pedagogical discourse.The explanation of unknown concepts and phenomena by referring to the formed units of knowledge prese

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Discovery of a high-performance phage-derived promoter/repressor system for probiotic lactobacillus engineering

Abstract Background The Lactobacillaceae family comprises many species of great importance for the food and healthcare industries, with numerous strains identified as beneficial for humans and used as probiotics.Hence, there is a growing interest in engineering these probiotic bacteria as live biotherapeutics for animals and humans.However, the gen

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Generation and characterization of Kctd15 mutations in zebrafish.

Potassium channel tetramerization domain containing 15 (Kctd15) was previously found to have a role in early neural crest solo jec 10 (NC) patterning, specifically delimiting the region where NC markers are expressed via repression of transcription factor AP-2a and inhibition of Wnt signaling.We used transcription activator-like effector nucleases

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